Translational Software
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The PGx Toolkit

Built for clinical environments.
Designed to keep data local.

The PGx Toolkit runs inside your environment—behind your firewall—so no protected health information (PHI) ever leaves your control.

The API provides curated pharmacogenomic insights. All patient data, demographics, and report generation remain entirely within your infrastructure.

PGx Toolkit architecture — cloud-hosted Knowledgebase and API server on the left (Azure Hosted); Test Results, Demographics, Toolkit Utilities, and Reports on the right (Internal To Customer). Test Results travel from the customer to the API; Insights travel back. PHI never crosses the boundary.
A clear separation between cloud-based knowledge services and on-premise processing ensures security, flexibility, and auditability.
Inputs

Bring your data. Keep it local.

  • Test results from any platform (VCF, arrays, instrument outputs)
  • Patient demographics (CSV, HL7, LIMS)
  • Lab-specific configuration and workflows
Transformation

A controlled, deterministic pipeline.

A lightweight executable runs within your environment to:

  • Retrieve curated pharmacogenomic insights via API
  • Combine results with patient and lab demographics
  • Apply rule-based matching to generate clinically relevant outputs
  • Select report templates and stylesheets based on context
Outputs

Reports tailored to your workflow.

  • Clinician-ready PDF reports
  • Configurable templates and stylesheets
  • Targeted outputs (e.g., psychotropics, CYP genes)
  • Customizable content tuned to your practice
  • Structured data for downstream systems
Architecture

Separation of concerns by design.

The toolkit cleanly separates the knowledge that should be centrally curated from the workflows that must stay close to the patient.

Knowledge Layer (API)
  • Normalization and mapping to curated recommendations
  • Continuously updated clinical content
  • No patient context required
Execution Layer (Your Environment)
  • Patient demographics and lab integration
  • Report generation and customization
  • Validation, verification, and audit workflows
Identity & Access

Enterprise authentication. Customer-controlled authorization.

  • OAuth authentication via Microsoft (including federated domains) or Google
  • Compatible with enterprise identity systems (e.g., Office 365)
  • Authorization fully managed by the customer
  • Role-based access control (RBAC) governs API usage, UI access, and validation and verification features
Supported Platforms

Works with the instruments your lab already runs.

The PGx Toolkit normalizes results from the major pharmacogenomic platforms — bring your existing data and keep your workflow intact.

Thermo Fisher Scientific

A comprehensive PGx portfolio spanning targeted PCR assays, genome-wide microarrays, and next-generation sequencing.

Illumina

A specialized ecosystem of microarrays, high-throughput sequencing platforms, and informatics designed to streamline PGx workflows from sample to report.

Agena Bioscience

PGx solutions centered on the proprietary MassARRAY System — MALDI-TOF mass spectrometry for high-throughput, cost-effective genetic analysis with results often within an 8-hour shift.

A complete, defensible pipeline.

The PGx Toolkit provides everything needed to:

  • Process pharmacogenomic data from any source
  • Match results to curated clinical guidance
  • Generate tailored, audit-ready reports
  • Maintain full control of patient data within your environment
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