Clinically Actionable Intelligence
Translational™ provides pharmacogenomic (PGx) reporting for drugs used in cardiology, psychiatry, neurology, pain treatment, oncology, and more. Our solutions transform pharmacogenetic test results into concise, actionable reports for physicians. Reports incorporate the latest guidance from scientific groups (e.g., the Clinical Pharmacogenetics Implementation Consortium (CPIC) and the Dutch Pharmacogenetics Working Group (DPWG)), governments (e.g., the Federal Drug Administration (FDA) and the European Medicines Agency (EMA)), and leading-edge science. Our experts carefully curate this information such that it can be delivered on-demand.
How Genotype Affects Drug Response
Clinicians recognize that patients respond to medications in different ways. They are accustomed to trying multiple drugs to find one that works, and wondering whether lack of efficacy is a mask for noncompliance or even drug abuse. For many common prescriptions, a simple genetic test can provide insight into the likely efficacy or toxicity of a drug, allowing a physician to choose safer and more effective treatments. Avoiding the need to re-do a stent, preventing an adverse reaction, or reducing an elderly patient’s mental fog can all significantly reduce health care costs – not to mention quality of life for the patient. Approximately 18% of prescriptions in the U.S. are for drugs that have clinically actionable guidance for particular genotypes (Nature, 2015).